Colorectal cancer peritoneal metastases: Biology, treatment and next steps
نویسندگان
چکیده
منابع مشابه
Treatment of peritoneal metastases from colorectal cancer
Peritoneal seedings of a colorectal tumor represent the second most frequent site of metastasis (after the liver). In the era of 5-fluorouracil (5-FU)-only chemotherapy, the prognosis was poor for colorectal cancer with peritoneal metastases. Within the last few years, new chemotherapeutic and targeted agents have improved the prognosis; however, the response to these treatments seems to be low...
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Peritoneum is one of the common sites of metastasis in advanced stage colorectal cancer patients. Colorectal cancer patients with peritoneal metastases (PM) are traditionally believed to have poor prognosis, which indicates it is of no value to adopt surgical treatment. With the advancement of surgical techniques, hyperthermic intraperitoneal chemotherapy (HIPEC), and multidisciplinary treatmen...
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BACKGROUND The optimal treatment of peritoneal carcinomatosis of colorectal origin appears to be a combination of systemic chemotherapy and complete surgical cytoreduction with synchronous intraperitoneal chemotherapy. The aim of this study was to assess the feasibility of, and outcomes following, surgical treatment and systemic chemotherapy alone. METHODS Prospectively collated data from the...
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Results: A total number of 893 patients with advanced colon cancer who presented as stage IV with peritoneal metastases as first presentation have been involved in this study. The most significant finding in these studies is the role of systemic chemotherapy either given as neoadjuvant, adjuvant or combined modality. The addition of Bevazucimab as vascular endothelial growth factor (VEGF) was a...
متن کاملPatient selection for cytoreductive surgery and HIPEC for the treatment of peritoneal metastases from colorectal cancer
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is a viable option for selected patients with peritoneal metastases (PM) from colorectal origin, resulting in long-term survival and even cure in some cases. However, adequate patient selection for this treatment is currently one of the major challenges. The aim of this review is to provide a comprehensive overvie...
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ژورنال
عنوان ژورنال: European Journal of Surgical Oncology
سال: 2020
ISSN: 0748-7983
DOI: 10.1016/j.ejso.2019.10.035